Edward Gogol
Electron Microscopy Lab
Members of the Lab
Sergiy Sukhanov, PhD.
Simon Low
Scott Falke
Latest 3D Reconstructions
GroEL (top) and GroEL with Glutamine Synthetase Bound (Bottom) - Reconstruction by Scott Falke
20S proteasome from red blood cells - Reconstruction by Simon Low
Top: Water activated 20S Middle: Water activated 20S with PI31 bound Bottom: Latent 20S
Click on image for larger version
Current Colaborations
Dr. George DeMartino - University of Texas Southwertern Medical Center
Dr. Mark Fisher - University of Kansas Medical Center
Dr. Gerald Carlson - University of Missouri - Kansas City
Recent Publications
Falke S, Fisher MT, Gogol EP.
Structural changes in GroEL effected by binding a denatured protein substrate.
J Mol Biol. 2001 May 11;308(4):569-77.
Falke S, Fisher MT, Gogol EP.
Classification and reconstruction of a heterogeneous set of electron microscopic images: a case study of groel-substrate complexes.
J Struct Biol. 2001 Feb;133(2-3):203-13.
Adams GM, Crotchett B, Slaughter CA, DeMartino GN, Gogol EP.
Formation of proteasome-PA700 complexes directly correlates with activation of peptidase activity.
Biochemistry. 1998 Sep 15;37(37):12927-32.
Adams GM, Falke S, Goldberg AL, Slaughter CA, DeMartino GN, Gogol EP.
Structural and functional effects of PA700 and modulator protein on proteasomes.
J Mol Biol. 1997 Oct 31;273(3):646-57.
Other Sites of Interest
The 3D Electron Microscopy Home Page
UMKC Biophysics Research Discussion Group