Edward Gogol

Electron Microscopy Lab

Members of the Lab

Edward Gogol, PhD.

Sergiy Sukhanov, PhD.

Simon Low

Scott Falke

Latest 3D Reconstructions

GroEL (top) and GroEL with Glutamine Synthetase Bound (Bottom) - Reconstruction by Scott Falke


20S proteasome from red blood cells - Reconstruction by Simon Low

Top: Water activated 20S Middle: Water activated 20S with PI31 bound Bottom: Latent 20S

Click on image for larger version

Current Colaborations

Dr. George DeMartino - University of Texas Southwertern Medical Center

Dr. Mark Fisher - University of Kansas Medical Center

Dr. Gerald Carlson - University of Missouri - Kansas City

Recent Publications


Falke S, Fisher MT, Gogol EP.

Structural changes in GroEL effected by binding a denatured protein substrate.

J Mol Biol. 2001 May 11;308(4):569-77.


Falke S, Fisher MT, Gogol EP.

Classification and reconstruction of a heterogeneous set of electron microscopic images: a case study of groel-substrate complexes.

J Struct Biol. 2001 Feb;133(2-3):203-13.


Adams GM, Crotchett B, Slaughter CA, DeMartino GN, Gogol EP.

Formation of proteasome-PA700 complexes directly correlates with activation of peptidase activity.

Biochemistry. 1998 Sep 15;37(37):12927-32.


Adams GM, Falke S, Goldberg AL, Slaughter CA, DeMartino GN, Gogol EP.

Structural and functional effects of PA700 and modulator protein on proteasomes.

J Mol Biol. 1997 Oct 31;273(3):646-57.


Other Sites of Interest

The 3D Electron Microscopy Home Page

The Chaperonin Home Page

UMKC Biophysics Research Discussion Group

The Yoder Lab Web Page